S516 Inhibitor

Name: S516 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753862
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753862

S516 is an active CKD-516 metabolite and is a potent inhibitor of tubulin polymerization(IC50 of 4.29 uM), has marked antitumor activity. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

S516, Inhibitor

Full Product Name

S516

Product Gene Name

S516, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

437.47

Solubility

DMSO: 12.5mg/mL (28.57mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C21H19N5O4S

SMILES

O=C(C1=CC=C(C2=CSC(N)=N2)C=C1N3N=CN=C3)C4=CC(OC)=C(OC)C(OC)=C4

CAS Number

1016543-77-3

Target & IC50

tubulin polymerization: ic50 4.29uM

In Vitro

In human LX-1 lung cancer and CX-1 colon cancer mouse xenografts,S516 (5-10mg/kg; intraperitoneal injection; mice) treatment,has promising antitumor activity (inhibition ratio (IR)> 63%).

Product Categories/Family for S516, inhibitor

Cytoskeletal Signaling; Microtubule Associated

Product References and Citations for S516, inhibitor

Lee J, et al. Identification of CKD-516: a potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors. J Med Chem. 2010 Sep 9;53(17):6337-54.

Other Notes

Small volumes of S516, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for S516 purchase

MBS5753862 is an inhibitor targeting S516.