S55746 Inhibitor

Name: S55746 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753863
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753863

S55746 is an effective and selective BCL-2 inhibitor (Ki: 1.3nM and a Kd of 3.9nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

S55746, Inhibitor

Full Product Name

S55746

Product Gene Name

S55746, inhibitor

Product Synonym Names

BLC201

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

710.82

Solubility

DMSO: 50mg/mL (70.34mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C43H42N4O6

SMILES

O=C(C1=C2CCCCN2C(C3=C(C(N4CC5=C(C=CC=C5)C[C@H]4CN6CCOCC6)=O)C=C(OCO7)C7=C3)=C1)N(C8=CC=C(O)C=C8)C9=CC=CC=C9

CAS Number

1448584-12-0

Target & IC50

Bcl-2: ic50 3.9nM (kd)
Bcl-xL: ic50 186nM (kd)

In Vitro

S55746 is a highly efficacious and well-tolerated (even at doses up to 300mg/kg) orally active BCL-2 inhibitor. S55746 (20-100mg/kg, p.o.) inhibits xenograft growth in RS4 [1].

Product Categories/Family for S55746, inhibitor

Apoptosis; BCL

Product References and Citations for S55746, inhibitor

Casara P, et al. S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth. Oncotarget. 2018 Apr 13;9(28):20075-20088.
Casara P, et al. S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth. Oncotarget. 2018 Apr 13;9(28):20075-20088.

Other Notes

Small volumes of S55746, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for S55746 purchase

MBS5753863 is an inhibitor targeting S55746.