SB-657510 Inhibitor

Name: SB-657510 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753873
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753873

MBS5753873 is an inhibitor targeting SB-657510. SB-657510 is a selective antagonist of urotensin II (UII) receptor (UT). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SB-657510, Inhibitor

Full Product Name

SB-657510

Product Gene Name

SB-657510, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

505.81

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C19H22BrClN2O5S

SMILES

ClC(C=C1)=C(O[C@H]2CN(C)CC2)C=C1NS(C3=CC(OC)=C(OC)C=C3Br)(=O)=O

CAS Number

474960-44-6

Target & IC50

Others

In Vitro

the progression of high-fat diet induced atherosclerosis and diabetes-associated atherosclerosis inhibited by SB-657510[1]. Levels of phosphorylated ERK are significantly attenuated in the aorta of SB-657510-treated (30mg/kg/day) diabetic mice (Male Apoe KO mice)[3].

Product References and Citations for SB-657510, inhibitor

Park SL, et al. Inhibitory Effect of an Urotensin II Receptor Antagonist on Proinflammatory Activation Inducedby Urotensin II in Human Vascular Endothelial Cells. Biomol Ther (Seoul). 2013 Jul 30;21(4):277-83.
Park SL, et al. Inhibitory Effect of an Urotensin II Receptor Antagonist on Proinflammatory Activation Inducedby Urotensin II in Human Vascular Endothelial Cells. Biomol Ther (Seoul). 2013 Jul 30;21(4):277-83.
Behm DJ, et al. Palosuran inhibits binding to primate UT receptors in cell membranes but demonstrates differential activity in intact cells and vascular tissues. Br J Pharmacol. 2008 Oct;155(3):374-86.
Behm DJ, et al. Palosuran inhibits binding to primate UT receptors in cell membranes but demonstrates differential activity in intact cells and vascular tissues. Br J Pharmacol. 2008 Oct;155(3):374-86.
Watson AM, et al. Urotensin II receptor antagonism confers vasoprotective effects in diabetes associated atherosclerosis: studies in humans and in a mouse model of diabetes. Diabetologia. 2013 May;56(5):1155-65.
Watson AM, et al. Urotensin II receptor antagonism confers vasoprotective effects in diabetes associated atherosclerosis: studies in humans and in a mouse model of diabetes. Diabetologia. 2013 May;56(5):1155-65.

Other Notes

Small volumes of SB-657510, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

SB-657510 Inhibitor

Product Overview

Structure of SB-657510, inhibitor

Related Product Information for SB-657510, inhibitor

Product References and Citations for SB-657510, inhibitor

Other Notes