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SB290157 Inhibitor – Trifluoroacetate

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753877

SB290157 trifluoroacetate is a potent and selective antagonist of C3a receptor(IC50 of 200nM). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SB290157 trifluoroacetate, Inhibitor
Full Product Name
SB290157 trifluoroacetate
Product Gene Name
SB290157, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
526.51
Solubility
DMSO: 125mg/mL (237.41mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C24H29F3N4O6
SMILES
OC(=O)C(F)(F)F.NC(=N)NCCC[C@H](NC(=O)COCC(c1ccccc1)c1ccccc1)C(O)=O
CAS Number
1140525-25-2
Target & IC50
C3a: ic50 200nM
In Vitro
Neutrophil recruitment in a guinea pig LPS-induced airway neutrophilia model inhibited by SB 290157,SB 290157 decreases paw edema in a rat adjuvant-induced arthritis model[1]. The antagonist is able to reduce joint swelling only at 3 h, and about 50% inhibition of joint swelling is observed with the concentration of 30mg/kg. The C3 level is significantly decreased at 3 hours compared with naive mice showing complement consumption. Furthermore, the C3 activation is observed and increased corresponding to the graded concentration of anti-OVA pAb[2].

Structure of SB290157, inhibitor

SB290157 Inhibitor – Cat# MBS5753877

Product References and Citations for SB290157, inhibitor

Ames RS, et al. Identification of a selective nonpeptide antagonist of the anaphylatoxin C3areceptor that demonstrates antiinflammatory activity in animal models. J Immunol. 2001 May 15;166(10):6341-8.
Ames RS, et al. Identification of a selective nonpeptide antagonist of the anaphylatoxin C3areceptor that demonstrates antiinflammatory activity in animal models. J Immunol. 2001 May 15;166(10):6341-8.
Hutamekalin P, et al. Effect of the C3a-receptor antagonist SB 290157 on anti-OVA polyclonalantibody-induced arthritis. J Pharmacol Sci. 2010;112(1):56-63.
Hutamekalin P, et al. Effect of the C3a-receptor antagonist SB 290157 on anti-OVA polyclonalantibody-induced arthritis. J Pharmacol Sci. 2010;112(1):56-63.

Other Notes

Small volumes of SB290157, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SB290157 purchase

MBS5753877 is an inhibitor targeting SB290157. Also known as SB290157 trifluoroacetate.
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