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SC57666 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753884

MBS5753884 is an inhibitor targeting SC57666. SC57666 is a selective inhibitor of COX2(IC50 of 26nM). More details

Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SC57666, Inhibitor
Full Product Name
SC57666
Product Gene Name
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
316.39
Solubility
DMSO: 100mg/mL (316.07mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C18H17FO2S
SMILES
O=S(C1=CC=C(C2=C(C3=CC=C(F)C=C3)CCC2)C=C1)(C)=O
CAS Number
158959-32-1
Target & IC50
COX-2: ic50 26nM
In Vitro
In the adjuvant-induced arthritis model,SC57666 has orally active with ED50 of 1.7mpk. when SC57666 is administered intragastrically at 600mpk,no gastric lesions are observed in mice after 5 hours. No intestinal damage is observed in rats after 72 h when SC57666 is administered intragastrically at 200mpk[1].

Structure of SC57666, inhibitor

SC57666 Inhibitor – Cat# MBS5753884

Product References and Citations for SC57666, inhibitor

Reitz DB, et al. Selective cyclooxygenase inhibitors: novel 1,2-diarylcyclopentenes are potent and orally activeCOX2 inhibitors. J Med Chem. 1994 Nov 11;37(23):3878-81.
Reitz DB, et al. Selective cyclooxygenase inhibitors: novel 1,2-diarylcyclopentenes are potent and orally activeCOX2 inhibitors. J Med Chem. 1994 Nov 11;37(23):3878-81.
Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17.
Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17.

Other Notes

Small volumes of SC57666, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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