SHA68 Inhibitor – SHA 68

Name: SHA68 Inhibitor; SHA 68; MyBioSource
Brand: MyBioSource
SKU: MBS5753904
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753904

SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR)(NPSR Asn107 and NPSR Ile107 with IC50s of 22.0 and 23.8nM, respectively). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

SHA 68 (SHA68), Inhibitor

Full Product Name

SHA 68

Product Gene Name

SHA68, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

445.49

Solubility

DMSO: 250mg/mL (561.18mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C26H24FN3O3

SMILES

O=C(N1CC2N(C(OC2(C3=CC=CC=C3)C4=CC=CC=C4)=O)CC1)NCC5=CC=C(F)C=C5

CAS Number

847553-89-3

Target & IC50

Asn107: ic50 22nM
Ile107: ic50 23.8nM

In Vitro

SHA 68 (i.p.; 5 and 50mg/kg) reduces NPS-induced horizontal activity and vertical rearing and climbing[1].SHA 68 (i.v.; 1mg/kg) has a T1/2 of 0.74 hours, a CL of 4.29mL/min/kg, and a Vss of 2.53L/kg.SHA 68 (i.p.; 2.5mg/kg) has a T1/2 of 0.43 hours, a CL of 4.56mL/min/kg[1].

Product References and Citations for SHA68, inhibitor

Okamura N, et al. Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptor.J Pharmacol Exp Ther. 2008 Jun;325(3):893-901.
Okamura N, et al. Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptor.J Pharmacol Exp Ther. 2008 Jun;325(3):893-901.
Ensho T, et al. Neuropeptide S increases motor activity and thermogenesis in the rat through sympathetic activation.Neuropeptides. 2017 Oct;65:21-27.
Ensho T, et al. Neuropeptide S increases motor activity and thermogenesis in the rat through sympathetic activation.Neuropeptides. 2017 Oct;65:21-27.

Other Notes

Small volumes of SHA68, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SHA68 purchase

MBS5753904 is an inhibitor targeting SHA68. Also known as SHA 68.

SHA68 Inhibitor – SHA 68

Product Overview

Structure of SHA68, inhibitor

Related Product Information for SHA68, inhibitor

Product References and Citations for SHA68, inhibitor

Other Notes

Searchable Terms for SHA68 purchase