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SK1-IN-1 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753924

MBS5753924 is an inhibitor targeting SK1-IN-1. SK1-IN-1 is a potent inhibitor of sphingosine kinase 1 (SPHK1)(IC50 of 58nM). More details

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Product Documentation
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Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SK1-IN-1, Inhibitor
Full Product Name
SK1-IN-1
Product Gene Name
SK1-IN-1, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
398.5
Solubility
DMSO: 100mg/mL (250.94mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C22H30N4O3
SMILES
O=C([C@H]1NCC[C@@H]1O)N[C@H](C2=CC=C(C3=NOC(CCC4CCCC4)=N3)C=C2)C
CAS Number
1218816-71-7
Target & IC50
SPHK1: ic50 58nM
In Vitro
SK1-IN-1 shows significant improvement in the intrinsic clearance, particularly against human liver microsomes. SK1-IN-1 is selected for rat PK studies and demonstrates modest in oral bioavailability with acceptable half-lives in blood circulation.

Product Categories/Family for SK1-IN-1, inhibitor

GPCR/G Protein; S1P Receptor

Structure of SK1-IN-1, inhibitor

SK1-IN-1 Inhibitor – Cat# MBS5753924

Product References and Citations for SK1-IN-1, inhibitor

Xiang Y, et al. Discovery of novel sphingosine kinase-1 inhibitors. Part 2. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4550-

Other Notes

Small volumes of SK1-IN-1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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