SNDX-5613 Inhibitor

Name: SNDX-5613 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753933
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753933

SNDX-5613 is a potent and specific inhibitor of Menin-MLL(Ki of 0.149nM and a cell based IC50 of 10-20nM). SNDX-5613 can be used for the research of MLL-rearranged (MLL-r) acute leukemias. More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SNDX-5613, Inhibitor

Full Product Name

SNDX-5613

Product Gene Name

SNDX-5613, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

630.82

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C32H47FN6O4S

SMILES

O=C(N(CC)C(C)C)C1=CC(F)=CC=C1OC2=CN=CN=C2N3CC4(CCN(C[C@H]5CC[C@H](NS(=O)(CC)=O)CC5)CC4)C3

CAS Number

2169919-21-3

Target & IC50

Menin-MLL

In Vitro

SNDX-5613 treatment,provides significant survival benefit and leukemic control in aggressive MOLM-13 disseminated xenografts.SNDX-5613 shows in vivo plasma(IC50 : 53nM).

Product Categories/Family for SNDX-5613, inhibitor

Chromatin/Epigenetic; Histone Methyltransferase

Product References and Citations for SNDX-5613, inhibitor

A drug, SNDX-5613, to treat acute leukemia with a KMT2A translocation or an NPM1 mutation that has come back (relapsed) or has not gotten better with treatment,(refractory).

Other Notes

Small volumes of SNDX-5613, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SNDX-5613 purchase

MBS5753933 is an inhibitor targeting SNDX-5613.