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PSI-7976 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753943

PSI-7976 is the isomer of PSI-7977. In the HCV replicon assay, PSI-7977 is an active inhibitor of HCV RNA replication, demonstrates effective anti-hepatitis C virus (HCV) activity. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
PSI-7976, Inhibitor
Full Product Name
PSI-7976
Product Gene Name
PSI-7976, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
529.45
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C22H29FN3O9P
SMILES
O=[P@](N[C@@H](C)C(OC(C)C)=O)(OC[C@@H]1[C@@H](O)[C@](F)(C)[C@H](N2C=CC(NC2=O)=O)O1)OC3=CC=CC=C3
CAS Number
1190308-01-0
Target & IC50
Others
In Vitro
PSI-7851 is a mixture of two diastereoisomers, PSI-7976 and PSI-7977. In the HCV replicon assay, with PSI-7977 being the more active inhibitor of HCV RNA replication. The kinetic data also indicates that PSI-7976 is a better substrate for CES1 than for cathepsin A (CatA). Carboxylesterase 1 (CES1) preferentially hydrolyzes PSI-7976 over PSI-7977 [1]

Structure of PSI-7976, inhibitor

PSI-7976 Inhibitor – Cat# MBS5753943

Product References and Citations for PSI-7976, inhibitor

Murakami E, et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. J Biol Chem. 2010 Nov 5;285(45):34337-47.
Murakami E, et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. J Biol Chem. 2010 Nov 5;285(45):34337-47.

Other Notes

Small volumes of PSI-7976, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PSI-7976 purchase

MBS5753943 is an inhibitor targeting PSI-7976.
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