BI-3406 Inhibitor

Name: BI-3406 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753960
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753960

BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 of 6nM),with anticancer activity. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

BI-3406, Inhibitor

Full Product Name

BI-3406

Product Gene Name

BI-3406, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

462.46

Solubility

DMSO: 95mg/ml (205.42mM) Need ultrasonic
Ethanol: 100mg/mL (216.23mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C23H25F3N4O3

SMILES

COC1=C(O[C@H]2CCOC2)C=C2C(N[C@H](C)C3=CC(=CC(N)=C3)C(F)(F)F)=NC(C)=NC2=C1

CAS Number

2230836-55-0

Target & IC50

KRAS-SOS1: ic50 6nM

Product Categories/Family for BI-3406, inhibitor

MAPK; Ras; GPCR/G Protein

Product References and Citations for BI-3406, inhibitor

Michael Gmachl, et al. Novel benzylamino substituted quinazolines and derivatives as sos1 inhibitors. WO2018115380A1.
Marco H Hofmann, et al. Abstract PL06-01: Discovery of BI-3406: A potent and selective SOS1::KRAS inhibitor opens a new approach for treating KRAS-driven tumors. December 2019.
Marco H Hofmann, et al. Abstract PL06-01: Discovery of BI-3406: A potent and selective SOS1::KRAS inhibitor opens a new approach for treating KRAS-driven tumors. December 2019.
Michael Gmachl, et al. Novel benzylamino substituted quinazolines and derivatives as sos1 inhibitors. WO2018115380A1.

Other Notes

Small volumes of BI-3406, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BI-3406 purchase

MBS5753960 is an inhibitor targeting BI-3406.