SPD304 Inhibitor

SPD304 is a selective TNF-alpha inhibitor and blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22uM for inhibiting in vitro TNF receptor 1 binding to TNF-alpha.

Molly M. He, et al. Small-Molecule Inhibition of TNF-alpha. Science 11 Nov 2005.
Molly M. He, et al. Small-Molecule Inhibition of TNF-alpha. Science 11 Nov 2005.
Alexiou P, et al. Rationally designed less toxic SPD-304 analogs and preliminary evaluation of their TNF inhibitory effects. Arch Pharm (Weinheim). 2014 Nov;347(11):798-805.
Alexiou P, et al. Rationally designed less toxic SPD-304 analogs and preliminary evaluation of their TNF inhibitory effects. Arch Pharm (Weinheim). 2014 Nov;347(11):798-805.
Mouhsine H, et al. Identification of an in vivo orally active dual-binding protein-protein interaction inhibitor targeting TNFalpha through combined in silico/in vitro/in vivo screening. Sci Rep. 2017 Jun 13;7(1):3424.
Mouhsine H, et al. Identification of an in vivo orally active dual-binding protein-protein interaction inhibitor targeting TNFalpha through combined in silico/in vitro/in vivo screening. Sci Rep. 2017 Jun 13;7(1):3424.
Gallic acid induces necroptosis via TNF-alpha signaling pathway in activated hepatic stellate cells. Chang YJ, et al. PLoS One. 2015 Mar 27;10(3):e0120713.
Gallic acid induces necroptosis via TNF-alpha signaling pathway in activated hepatic stellate cells. Chang YJ, et al. PLoS One. 2015 Mar 27;10(3):e0120713.

Small volumes of SPD304, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5753961 is an inhibitor targeting SPD304.