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STING Inhibitor – Agonist-3

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753974

STING agonist-3 is a selective and non-nucleotide small-molecule STING agonist(pEC50 and pIC50 of 7.5 and 9.5, respectively), has durable anti-tumor effect and tremendous potential to improve treatment,of cancer. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
STING agonist-3, Inhibitor
Full Product Name
STING agonist-3
Product Gene Name
STING, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
750.81
Solubility
DMSO: 125mg/mL (166.49mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C37H42N12O6
SMILES
O=C(N)C1=CC=C(N(C(NC(C2=CC(C)=NN2CC)=O)=N3)C/C=C/CN4C5=C(N=C4NC(C6=CC(C)=NN6CC)=O)C=C(C(N)=O)C=C5OCCCO)C3=C1
CAS Number
2138299-29-1
Target & IC50
Others
In Vitro
STING agonist-3 exhibits activation of STING in cells(pEC50 of 7.5), this assay is determined using a luciferase reporter assay in human embryonic kidney cells (HEK293T) co-transfected with plasmids expressing STING and the enzyme firefly luciferase driven by the interferon stimulated response element promoter. In FRET assay, STING agonist-3 exhibits a pIC50 value of 9.5. This is a competition binding assay which aims to determine the binding potency of molecules to the C-terminal Domain (CTD) of human STING.

Structure of STING, inhibitor

STING Inhibitor – Cat# MBS5753974

Product References and Citations for STING, inhibitor

Adam Kenneth, et al. Heterocyclic amides useful as protein modulators.patent WO2017175147A1

Other Notes

Small volumes of STING, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for STING purchase

MBS5753974 is an inhibitor targeting STING. Also known as STING agonist-3.
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