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STL127705 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753977

STL127705 is a inhibitor of Ku 70/80 heterodimer protein(Ku70/80-DNA interaction, with an IC50 of 3.5uM). STL127705 also inhibits Ku-dependent activation of DNA-PKCS kinase (IC50, 2.5uM). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
STL127705, Inhibitor
Full Product Name
STL127705
Product Gene Name
STL127705, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
437.42
Solubility
H2O: <0.1mg/mL (insoluble)
DMSO: <1mg/mL (insoluble or slightly soluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C22H20FN5O4
SMILES
O=C1NC2=NC(NCCC3=CC=C(OC)C(OC)=C3)=NC=C2C(N1C4=CC=CC(F)=C4)=O
CAS Number
1326852-06-5
Target & IC50
Ku 70/80: ic50 3.5uM
DNA-PKCS: ic50 2.5uM

Structure of STL127705, inhibitor

STL127705 Inhibitor – Cat# MBS5753977

Product References and Citations for STL127705, inhibitor

Weterings E, et al. A novel small molecule inhibitor of the DNA repair protein Ku70/80. DNA Repair (Amst). 2016 Jul;43:98-106.

Other Notes

Small volumes of STL127705, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for STL127705 purchase

MBS5753977 is an inhibitor targeting STL127705.
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