SUN1334H Inhibitor – SUN 1334h

Name: SUN1334H Inhibitor; SUN 1334h; MyBioSource
Brand: MyBioSource
SKU: MBS5753982
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753982

SUN 1334H is a potent, orally active, highly selective antagonist of H1 receptor(Ki of 9.7nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SUN 1334H (SUN1334H), Inhibitor

Full Product Name

SUN 1334H

Product Gene Name

SUN1334H, inhibitor

Product Synonym Names

Soluble sulfamerazine

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

489.38

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C23H28Cl2F2N2O3

SMILES

O=C(O)COC/C=C/CN1CCN(C(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3)CC1.[H]Cl.[H]Cl

CAS Number

607736-84-5

Target & IC50

H1 receptor(ki): ic50 9.7nM (ki)

In Vitro

In beagle dogs and ovalbumin-induced rhinitis in guinea pigs, SUN-1334H potently inhibits histamine-induced bronchospasm over 24 hours following oral administration and completely suppresses histamine-induced skin wheal [1]. SUN-1334H shows potent reduction of passive and active cutaneous anaphylactic reactions in skin allergy models. In central nervous system side effects models, SUN-1334H, desloratadine and fexofenadine are devoid of any significant effects[2].

Product Categories/Family for SUN1334H, inhibitor

GPCR/G Protein; Histamine Receptor; Immunology/Inflammation; Neuroscience

Product References and Citations for SUN1334H, inhibitor

Mandhane SN, et al. Preclinical efficacy and safety pharmacology of SUN-1334H, a potent orally active antihistamine agent.
Mandhane SN, et al. Preclinical efficacy and safety pharmacology of SUN-1334H, a potent orally active antihistamine agent.
Mandhane SN, et al. Characterization of anti-inflammatory properties and evidence for no sedation liability for the novel
Mandhane SN, et al. Characterization of anti-inflammatory properties and evidence for no sedation liability for the novel

Other Notes

Small volumes of SUN1334H, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SUN1334H purchase

MBS5753982 is an inhibitor targeting SUN1334H. Also known as SUN 1334H.