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SY-1365 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753984

MBS5753984 is an inhibitor targeting SY-1365. SY-1365 is a highly selective covalent More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SY-1365, Inhibitor
Full Product Name
SY-1365
Product Gene Name
SY-1365, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
587.12
Solubility
DMSO: 125mg/mL (212.90mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C31H35ClN8O2
SMILES
O=C(C1=NC=C(NC(/C=C/CN(C)C)=O)C=C1)N[C@@]2(C)CCC[C@@H](NC3=NC=C(Cl)C(C4=CNC5=C4C=CC=C5)=N3)C2
CAS Number
1816989-16-8
Target & IC50
CDK7
In Vitro
In beagle dogs and ovalbumin-induced rhinitis in guinea pigs, SUN-1334H potently inhibits histamine-induced bronchospasm over 24 hours following oral administration and completely suppresses histamine-induced skin wheal [1]. SUN-1334H shows potent reduction of passive and active cutaneous anaphylactic reactions in skin allergy models. In central nervous system side effects models, SUN-1334H, desloratadine and fexofenadine are devoid of any significant effects[2].

Product Categories/Family for SY-1365, inhibitor

Cell Cycle/Checkpoint; CDK

Structure of SY-1365, inhibitor

SY-1365 Inhibitor – Cat# MBS5753984

Product References and Citations for SY-1365, inhibitor

Hu S, et al. Discovery and characterization of SY-1365, a selective, covalent inhibitor of CDK7. Cancer Res. 2019 May 7.

Other Notes

Small volumes of SY-1365, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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