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I-BET762 Inhibitor – Carboxylic Acid

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754008

MBS5754008 is an inhibitor targeting I-BET762. Also known as I-BET762 carboxylic acid. I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
I-BET762 carboxylic acid, Inhibitor
Full Product Name
I-BET762 carboxylic acid
Product Gene Name
I-BET762, inhibitor
Product Synonym Names
Molibresib carboxylic acid; GSK525762A carboxylic acid; PROTAC BRD4-binding moiety 2
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
396.83
Solubility
DMSO: 7.14mg/mL (17.99mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C20H17ClN4O3
SMILES
CC1=NN=C2[C@H](CC(O)=O)N=C(C3=CC=C(Cl)C=C3)C4=C(C=CC(OC)=C4)N21
CAS Number
1300019-38-8
Target & IC50
BRD4: ic50 5.1 (pIC50)
In Vitro
peripheral blood mononuclear cells (PBMC) inhibited by I-BET762 carboxylic acid(pIC50 of <4).

Product Categories/Family for I-BET762, inhibitor

Chromatin/Epigenetic; Epigenetic Reader Domain

Structure of I-BET762, inhibitor

I-BET762 Inhibitor – Cat# MBS5754008

Product References and Citations for I-BET762, inhibitor

Mirguet O, et al. Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains. J Med Chem. 2013 Oct 10;56(19):7501-15.

Other Notes

Small volumes of I-BET762, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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