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TAS-114 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754011

TAS-114 is a dual inhibitor of dUTPase/dihydropyrimidine dehydrogenase (DPD), and can improving the therapeutic efficacy of fluoropyrimidine. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TAS-114, Inhibitor
Full Product Name
TAS-114
Product Gene Name
TAS-114, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
451.54
Solubility
DMSO: 100mg/mL (221.46mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C21H29N3O6S
SMILES
O=S(CCCOCN(C(N1)=O)C=CC1=O)(N[C@@H](C2=CC=CC(OC3CCCC3)=C2)C)=O
CAS Number
1198221-21-4
Target & IC50
dUTPase, DPD
In Vitro
In mice, the antitumor activity of 5-FU when co-administers with Capecitabine (539mg/kg/day) increased by TAS-114 (37.5-1,200mg/kg/day; orally; 1-14 days).

Structure of TAS-114, inhibitor

TAS-114 Inhibitor – Cat# MBS5754011

Product References and Citations for TAS-114, inhibitor

Yano W, et al. TAS-114, a First-in-Class Dual dUTPase/DPD Inhibitor, Demonstrates Potential to Improve Therapeutic Efficacy of Fluoropyrimidine-Based Chemotherapy. Mol Cancer Ther. 2018 Aug;17(8):1683-1693.

Other Notes

Small volumes of TAS-114, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TAS-114 purchase

MBS5754011 is an inhibitor targeting TAS-114.
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