TAS4464 Inhibitor

Name: TAS4464 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754013
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754013

TAS4464 is a highly potent and selective inhibitor of the NEDD8 activating enzyme (IC50: 0.955nM). More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

TAS4464, Inhibitor

Full Product Name

TAS4464

Product Gene Name

TAS4464, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

506.51

Solubility

DMSO: 125mg/mL (246.79mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C21H23FN6O6S

SMILES

NC1=NC=NC2=C1C(C#CC3=C(F)C=CC=C3OCC)=CN2[C@@H]4O[C@H](CNS(=O)(N)=O)[C@@H](O)[C@H]4O

CAS Number

1848959-10-3

Target & IC50

NAE: ic50 0.955nM

Product Categories/Family for TAS4464, inhibitor

Ubiquitination; E1/E2/E3 Enzyme; Ubiquitination

Product References and Citations for TAS4464, inhibitor

Yoshimura C, et al. TAS4464, a highly potent and selective inhibitor of NEDD8 activating enzyme, suppresses neddylation and shows antitumor activity in diverse cancer models. Mol Cancer Ther. 2019 May 15.
Yoshimura C, et al. TAS4464, a highly potent and selective inhibitor of NEDD8 activating enzyme, suppresses neddylation and shows antitumor activity in diverse cancer models. Mol Cancer Ther. 2019 May 15.

Other Notes

Small volumes of TAS4464, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TAS4464 purchase

MBS5754013 is an inhibitor targeting TAS4464.