Tautomycin Inhibitor

Name: Tautomycin Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754015
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754015

Tautomycin is a potent and specific protein phosphatases 1 and 2A inhibitor (Kiapp of 0.16nM and 0.4nM for PP1 and PP2A, respectively), and is an antifungal antibiotic isolated from the bacterium Streptomyces verticillatus. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Tautomycin, Inhibitor

Full Product Name

Tautomycin

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

766.96

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C41H66O13

SMILES

C[C@@H]([C@]([C@H](CC1)C)([H])O[C@@]1(CC[C@H]2C)O[C@H]2CC[C@H](C)C(C)=O)CC[C@H](O)[C@H](C)C(C[C@@H](O)[C@H](OC)[C@@H](C(C)C)OC(C[C@H](C(C(O3)=O)=C(C3=O)C)O)=O)=O

CAS Number

109946-35-2

Target & IC50

PP1: ic50 0.16nM (Kiapp)
PP2A: ic50 0.4nM

In Vitro

MTC cell growth in a dose-dependent manner is inhibited by Tautomycin (0-1000nM, 48 hours) [2]. NE markers ASCL1 and CgA in human MTC cells are decreased in a dose-dependent manner by Tautomycin (0-1000nM, 48 hours)[2].

Product References and Citations for Tautomycin, inhibitor

MacKintosh C, et al. Tautomycin from the bacterium Streptomyces verticillatus. Another potent and specific inhibitor of protein phosphatases 1 and 2A. FEBS Lett. 1990 Dec 17;277(1-2):137-40.
MacKintosh C, et al. Tautomycin from the bacterium Streptomyces verticillatus. Another potent and specific inhibitor of protein phosphatases 1 and 2A. FEBS Lett. 1990 Dec 17;277(1-2):137-40.
Adler JT, et al. Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3beta. Mol Cancer Ther. 2009 Apr;8(4):914-20.
Adler JT, et al. Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3beta. Mol Cancer Ther. 2009 Apr;8(4):914-20.

Other Notes

Small volumes of Tautomycin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tautomycin purchase

MBS5754015 is an inhibitor targeting Tautomycin.

Tautomycin Inhibitor

Product Overview

Structure of Tautomycin, inhibitor

Related Product Information for Tautomycin, inhibitor

Product References and Citations for Tautomycin, inhibitor

Other Notes

Searchable Terms for Tautomycin purchase