TCASK10 Inhibitor – Tc ASK 10

Name: TCASK10 Inhibitor; Tc ASK 10; MyBioSource
Brand: MyBioSource
SKU: MBS5754018
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754018

TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1)(IC50 of 14nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TC ASK 10 (TCASK10), Inhibitor

Full Product Name

TC ASK 10

Product Gene Name

TCASK10, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

432.35

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C21H23Cl2N5O

SMILES

O=C(NC1=CN2C=C(N3C=CN=C3)C=CC2=N1)C4=CC=C(C(C)(C)C)C=C4.[H]Cl.[H]Cl

CAS Number

1005775-56-3

Target & IC50

ASK1: ic50 14nM

In Vitro

In rats, Pharmacokinetic profiles are tested. TC ASK 10 (rat cassette doing at 0.1mg/kg, iv and 1mg/kg, po.) has a good oral bioavailability. The Cmax, Tmax and AUCpo,0-8h are 285.1ng/mL, 1.67 h and 275.4 ng.h/mL, respectively for TC ASK 10.

Product Categories/Family for TCASK10, inhibitor

Apoptosis; ASK

Product References and Citations for TCASK10, inhibitor

Terao Y, et al. Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7326-9.

Other Notes

Small volumes of TCASK10, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TCASK10 purchase

MBS5754018 is an inhibitor targeting TCASK10. Also known as TC ASK 10.