Tiotidine Inhibitor

Tiotidine is a selective histamine H-receptor antagonist (pA2=7.3-7.8 for guinea-pig right atrium).

Barth H, et al. Structural requirements of imidazole compounds to be inhibitors or activators of histaminemethyltransferase: investigation of histamine analogues and H2-receptor antagonists.
Barth H, et al. Structural requirements of imidazole compounds to be inhibitors or activators of histaminemethyltransferase: investigation of histamine analogues and H2-receptor antagonists.
Trzeciakowski JP, et al. The cardiac pharmacology of tiotidine (LCL 125, 211): a new histamine H-receptor antagonist. J Pharmacol Exp Ther. 1980 Sep;214(3):629-34.
Trzeciakowski JP, et al. The cardiac pharmacology of tiotidine (LCL 125, 211): a new histamine H-receptor antagonist. J Pharmacol Exp Ther. 1980 Sep;214(3):629-34.
Monczor F, et al. Tiotidine, a histamine H receptor inverse agonist that binds with high affinity to an inactive G-protein-coupled form of the receptor. Experimental support for the cubic ternary complex model. Mol Pharmacol. 2003 Aug;64(2):512-20.
Monczor F, et al. Tiotidine, a histamine H receptor inverse agonist that binds with high affinity to an inactive G-protein-coupled form of the receptor. Experimental support for the cubic ternary complex model. Mol Pharmacol. 2003 Aug;64(2):512-20.

Small volumes of Tiotidine, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5754047 is an inhibitor targeting Tiotidine.