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TK216 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754049

TK216 is a potent inhibitor of E26 transformation-specific (ETS) with anticancer activity. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TK216, Inhibitor
Full Product Name
TK216
Product Gene Name
TK216, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
376.23
Solubility
DMSO: 249mg/mL (661.83mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C19H15Cl2NO3
SMILES
OC1(CC(=O)c2ccc(cc2)C2CC2)C(=O)Nc2c1c(Cl)ccc2Cl
CAS Number
1903783-48-1
Target & IC50
ETS
In Vitro
In the TMD-8 xenograft model, TK216 (po; 100mg/kg; twice daily for 13 days) results in tumor growth inhibition [1].

Structure of TK216, inhibitor

TK216 Inhibitor – Cat# MBS5754049

Product References and Citations for TK216, inhibitor

Spriano F, et al. The ETS Inhibitors YK-4-279 and TK-216 Are Novel Antilymphoma Agents. Clin Cancer Res. 2019 Aug 15;25(16):5167-5176.
Spriano F, et al. The ETS Inhibitors YK-4-279 and TK-216 Are Novel Antilymphoma Agents. Clin Cancer Res. 2019 Aug 15;25(16):5167-5176.
Brian Lannutti, et al. Uses of indolinone compounds. US10159660B2.
Brian Lannutti, et al. Uses of indolinone compounds. US10159660B2.

Other Notes

Small volumes of TK216, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TK216 purchase

MBS5754049 is an inhibitor targeting TK216.
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