• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

TMC647055 Inhibitor – Choline Salt

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754051

TMC647055 choline salt is a selective and cell-permeating inhibitor of HCV NS5B (IC50: 34nM). More details

Please Inquire
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TMC647055 Choline salt, Inhibitor
Full Product Name
TMC647055 Choline salt
Product Gene Name
TMC647055, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
727.91
Solubility
DMSO: 43mg/mL (59.07mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C37H53N5O8S
SMILES
OCC[N+](C)(C)C.COC1=CC2=C(C=C1)C3=C(C4CCCCC4)C5=CC=C(C6=O)C=C5N3CC(C(N(C)CCOCCN(S(N6)(=O)=O)C)=O)=C2.[OH-]
Target & IC50
Others
In Vitro
TMC647055 is a novel and potent nonnucleoside the HCV NS5B RNA-dependent RNA polymerase inhibitor. TMC647055 shows high selectivity for HCV when evaluated with a broad panel of human DNA and RNA viruses. TMC647055 shows median EC50 changes in the replicon assay of 9-, 3-, and 371-fold for L392I, V494A, and P495L, respectively, The median EC50 of TMC647055 on NS5B sequences derived from clinical isolates of genotypes 1a, 1b, 3a, 4a, and 6a ranged between 27nM and 113nM.

Structure of TMC647055, inhibitor

TMC647055 Inhibitor – Cat# MBS5754051

Product References and Citations for TMC647055, inhibitor

Devogelaere B, et al. TMC647055, a potent nonnucleoside hepatitis C virus NS5B polymerase inhibitor with cross-genotypic coverage. Antimicrob Agents Chemother. 2012 Sep;56(9):4676-4684.

Other Notes

Small volumes of TMC647055, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TMC647055 purchase

MBS5754051 is an inhibitor targeting TMC647055. Also known as TMC647055 Choline salt.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000