TL02-59 Inhibitor

Name: TL02-59 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754059
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754059

TL02-59 is an orally active inhibitor of Src-family kinase Fgr (IC50: 0.03nM), and potently suppresses acute myelogenous leukemia (AML) cell growth. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TL02-59, Inhibitor

Full Product Name

TL02-59

Product Gene Name

TL02-59, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

609.64

Solubility

DMSO: 125mg/mL (205.04mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C32H34F3N5O4

SMILES

O=C(NC1=CC=C(CN2CCN(CC)CC2)C(C(F)(F)F)=C1)C3=CC=C(C)C(OC4=C5C=C(OC)C(OC)=CC5=NC=N4)=C3

CAS Number

1315330-17-6

Target & IC50

Fgr: ic50 0.03nM
Lyn: ic50 0.1nM
Hck: ic50 160nM

In Vitro

In a mouse model of AML, TL02-59 oral administration (1 and 10mg/kg; for three weeks) completely eliminates AML cells from the spleen and peripheral blood, while dramatically suppressing bone marrow involvement. TL02-59 has a t1/2 of 5.7 h by i.v injection and 6.5 h by p.o. administration, respectively.

Product Categories/Family for TL02-59, inhibitor

Angiogenesis; Src; Tyrosine Kinase/Adaptors

Product References and Citations for TL02-59, inhibitor

Weir MC, et al. Selective Inhibition of the Myeloid Src-Family Kinase Fgr Potently Suppresses AML Cell Growth in Vitro and in Vivo. ACS Chem Biol. 2018 Jun 15;13(6):1551-1559.

Other Notes

Small volumes of TL02-59, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TL02-59 purchase

MBS5754059 is an inhibitor targeting TL02-59.