TyK2-IN-2 Inhibitor

Name: TyK2-IN-2 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754071
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754071

TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7nM, 0.1uM, and 0.05uM for TYK2 JH2, IL-23, and IFNalpha). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TyK2-IN-2, Inhibitor

Full Product Name

TyK2-IN-2

Product Gene Name

TyK2-IN-2, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

310.35

Solubility

DMSO: 25mg/mL (80.55mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C16H18N6O

SMILES

CNC1=CC(NC2=CC(C)=CC(C)=C2)=NN3C1=NC=C3C(N)=O

CAS Number

2098466-94-3

Target & IC50

Tyk2 JH2: ic50 7nM
PDE4: ic50 62nM

Product Categories/Family for TyK2-IN-2, inhibitor

Metabolism; PDE

Product References and Citations for TyK2-IN-2, inhibitor

Moslin R, et al. Identification of imidazo[1,2-b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling. Medchemcomm. 2016 Dec 15;8(4):700-712.

Other Notes

Small volumes of TyK2-IN-2, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TyK2-IN-2 purchase

MBS5754071 is an inhibitor targeting TyK2-IN-2.