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TYK2-IN-5 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754072

Tyk2-IN-5 is a selective and orally active inhibitor of Tyk2 JH2 (Ki: 0.086nM for Tyk2 JH2; IC50: 25nM for IFNalpha). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Tyk2-IN-5, Inhibitor
Full Product Name
Tyk2-IN-5
Product Gene Name
Tyk2-IN-5, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
434.43
Solubility
DMSO: 43.33mg/mL (99.74mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C21H19FN8O2
SMILES
O=C1C(NC2=NN3C(C(NC)=C2)=NC=C3C(N[C@H]4[C@@H](F)C4)=O)=CC=CN1C5=CC=CC=N5
CAS Number
1797432-62-2
Target & IC50
Tyk2 JH2: ic50 0.086nM (ki)
IFNalpha: ic50 25nM

Structure of Tyk2-IN-5, inhibitor

TYK2-IN-5 Inhibitor – Cat# MBS5754072

Product References and Citations for Tyk2-IN-5, inhibitor

Liu C, et al. Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors. ACS Med Chem Lett. 2019 Feb 21;10(3):383-388.

Other Notes

Small volumes of Tyk2-IN-5, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tyk2-IN-5 purchase

MBS5754072 is an inhibitor targeting Tyk2-IN-5.
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