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TYK2-IN-8 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754075

Tyk2-IN-8 is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain (IC50: 17nM). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Tyk2-IN-8, Inhibitor
Full Product Name
Tyk2-IN-8
Product Gene Name
Tyk2-IN-8, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
383.41
Solubility
DMSO: 16.67mg/mL (43.48mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C20H17N9
SMILES
N#CC[C@@]1(N2N=CC(C3=NC(C4=CN(C)N=C4)=CN5C3=CC=N5)=C2)C[C@@H](C#N)C1
CAS Number
2127109-84-4
Target & IC50
TYK2 JH1: ic50 17nM

Structure of Tyk2-IN-8, inhibitor

TYK2-IN-8 Inhibitor – Cat# MBS5754075

Product References and Citations for Tyk2-IN-8, inhibitor

1. Wrobleski ST, et al. Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the treatment,of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165. J Med Chem. 2019 Jul 18.

Other Notes

Small volumes of Tyk2-IN-8, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tyk2-IN-8 purchase

MBS5754075 is an inhibitor targeting Tyk2-IN-8.
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