UK-370106 Inhibitor

Name: UK-370106 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754078
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754078

UK-370106 is a potent and highly selective inhibitor of MMP-3 with IC50 of 23nM and MMP-12 with IC50 of 42nM, and potently inhibits cleavage of [3H]-fibronectin by MMP-3 (IC50: 320nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

UK-370106, Inhibitor

Full Product Name

UK-370106

Product Gene Name

UK-370106, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

572.73

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C35H44N2O5

SMILES

CC1=C(C2=CC=CC=C2)C=CC(CCC[C@H](CC(O)=O)C(N[C@@H](C(C)(C)C)C(N[C@@H](C3=CC=CC=C3)COC)=O)=O)=C1

CAS Number

230961-21-4

Target & IC50

MMP-3: ic50 23nM
MMP-12: ic50 42nM
MMP-8: ic50 1.75uM
MMP-13: ic50 2.3uM
MMP-7: ic50 5.8uM
MMP-9: ic50 30.4uM
MMP-2: ic50 34.2uM
MMP-14: ic50 66.9uM

In Vitro

Following iv (rat; 2mg/kg) or topical administration to dermal wounds (rabbit), UK-370106 (compound 7) is cleared rapidly (t1/2 = 23 min) from plasma, but slowly (t1/2 approximately 3 days) from dermal tissue. Topical administration of UK-370106 for 6 days substantially inhibitsmMP-3 ex vivo in a model of chronic dermal ulcers [1].

Product Categories/Family for UK-370106, inhibitor

Proteases/Proteasome; MMP

Product References and Citations for UK-370106, inhibitor

Fray MJ, et al. A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment,of chronic dermal ulcers. J Med Chem. 2003 Jul 31;46(16):3514-25.
Fray MJ, et al. A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment,of chronic dermal ulcers. J Med Chem. 2003 Jul 31;46(16):3514-25.
Whitlock GA, et al. A novel series of highly selective inhibitors of MMP-Bioorg Med Chem Lett. 2007 Dec 15;17(24):6750-Epub 2007 Oct 17.
Whitlock GA, et al. A novel series of highly selective inhibitors of MMP-3. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6750-3. Epub 2007 Oct 17.

Other Notes

Small volumes of UK-370106, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for UK-370106 purchase

MBS5754078 is an inhibitor targeting UK-370106.