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VBY-825 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754096

VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
VBY-825, Inhibitor
Full Product Name
VBY-825
Product Gene Name
VBY-825, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
535.55
Solubility
DMSO: 125mg/mL (233.40mM) Need ultrasonic
H2O: <0.1mg/mL (insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C23H29F4N3O5S
SMILES
CC[C@H](NC([C@@H](N[C@@H](C1=CC=C(F)C=C1)C(F)(F)F)CS(=O)(CC2CC2)=O)=O)C(C(NC3CC3)=O)=O
CAS Number
1310340-58-9
Target & IC50
Others
In Vitro
VBY-825 is a potent assayed cathepsins inhibitor and its potency against at least one cathepsin, cathepsin S, extends across species relevant for pharmacology studies, specifically mouse. 10mg/kg/day dose of VBY-825 achieves a trough plasma concentration >200nM, which is well above that required for full inhibition of the intracellular activity of cathepsins B, F, K, L, S and V in both mouse and human cell lines.

Structure of VBY-825, inhibitor

VBY-825 Inhibitor – Cat# MBS5754096

Product References and Citations for VBY-825, inhibitor

Elie BT, et al. Identification and pre-clinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor efficacy in a pancreatic cancer model. Biochimie. 2010 Nov;92(11):1618-24.

Other Notes

Small volumes of VBY-825, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VBY-825 purchase

MBS5754096 is an inhibitor targeting VBY-825.
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