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Seviteronel Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754112

Seviteronel is an effective CYP17 lyase inhibitor (h-Lyase IC50=69nM). In a hamster model of androgen biosynthesis inhibition, it demonstrated both exceptional in vitro lyase/hydroxylase selectivity (~10-fold) and oral activity. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Seviteronel, Inhibitor
Full Product Name
Seviteronel
Product Synonym Names
VT-464
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
399.34
Solubility
DMSO: 50mg/mL (125.21mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C18H17F4N3O3
SMILES
FC(F)OC1=C(OC(F)F)C=C(C=CC([C@](C2=CNN=N2)(C(C)C)O)=C3)C3=C1
CAS Number
1610537-15-9
Target & IC50
h-CYP17 Lyase: ic50 69nM

Structure of Seviteronel, inhibitor

Seviteronel Inhibitor – Cat# MBS5754112

Product References and Citations for Seviteronel, inhibitor

Sankar N. Maity, et al. Abstract 4772: Efficacy of VT-464, a novel selective inhibitor of cytochrome P450 17,20-lyase, in castrate-resistant prostate cancer models. Cancer Research: April 15, 2013; Volume 73, Issue 8, Supplement 1

Other Notes

Small volumes of Seviteronel, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Seviteronel purchase

MBS5754112 is an inhibitor targeting Seviteronel.
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