VTX-27 Inhibitor

Name: VTX-27 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754114
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754114

VTX-27 is a selective inhibitor of protein kinase C theta (PKC theta) (Kis: 0.08nM and 16nM for PKC theta and PKC delta). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

VTX-27, Inhibitor

Full Product Name

VTX-27

Product Gene Name

VTX-27, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

418.9

Solubility

DMSO: 125mg/mL (298.40mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C20H24ClFN6O

SMILES

FC1=C(N=C(N2C[C@@](NCC2)([H])[C@](C)(O)C(C)C)C(Cl)=C1)C3=NNC4=NC=CC=C34

CAS Number

1321924-70-2

Target & IC50

PKCtheta: ic50 0.08nM (ki)
PKCdelta: ic50 16nM (ki)
PKCalpha: ic50 356nM (ki)

In Vitro

VTX-27 shows the best PK profile with a low clearance (7mL min-1 kg-1), good oral bioavailability (65%), and long half-life (4.7 h). A single dose of VTX-27 is administered orally at 6.25, 12.5, 25, and 50mg/kg (e.g., at 25mg/kg Cmax concentration 700ng/mL) and demonstrates potent dose dependent inhibition of IL-2 production.

Product Categories/Family for VTX-27, inhibitor

Cytoskeletal Signaling; PKC

Product References and Citations for VTX-27, inhibitor

Jimenez JM, et al. Design and optimization of selective protein kinase C theta (PKCtheta) inhibitors for the treatment,of autoimmune diseases. J Med Chem. 2013 Mar 14;56(5):1799-810.

Other Notes

Small volumes of VTX-27, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VTX-27 purchase

MBS5754114 is an inhibitor targeting VTX-27.