VU6012962 Inhibitor

Name: VU6012962 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754122
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754122

VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

VU6012962, Inhibitor

Full Product Name

VU6012962

Product Gene Name

VU6012962, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

448.4

Solubility

DMSO: 125mg/mL (278.77mM) Need ultrasonic
H2O: <0.1mg/mL (insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C21H19F3N4O4

SMILES

O=C(C1=CC=C(OCC2CC2)C(OC)=C1)NC3=C(N4C=NC=N4)C=CC(OC(F)(F)F)=C3

Target & IC50

mGlu7: ic50 347nM

In Vitro

In the elevated zero maze (EZM) assay in mice, VU6012962 (1-10mg/kg; i.p. injection; 60 minutes prior to testing) decreases anxiety.

Product Categories/Family for VU6012962, inhibitor

Neuroscience; GluR

Product References and Citations for VU6012962, inhibitor

Reed CW, et al. Discovery of an orally bioavailable and Central Nervous System (CNS) penetrant mGlu7 NegativeAllosteric Modulator (NAM) in vivo tool compound: N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-4-(cyclopropylmethoxy)-3-methoxybenzamide (VU6012962). J Med Chem. 2019 Jan 4.

Other Notes

Small volumes of VU6012962, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VU6012962 purchase

MBS5754122 is an inhibitor targeting VU6012962.