Vofopitant Inhibitor

Name: Vofopitant Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754125
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754125

Vofopitant is a potent antagonist of the tachykinin NK1 receptor (pKis: 10.6, 9.5, and 9.8 for the human, rat, and ferret NK1 receptor, respectively). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Vofopitant, Inhibitor

Full Product Name

Vofopitant

Product Synonym Names

GR 205171

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

432.44

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C21H23F3N6O

SMILES

COC1=C(CN[C@@H]2[C@H](C3=CC=CC=C3)NCCC2)C=C(N4C(C(F)(F)F)=NN=N4)C=C1

CAS Number

168266-90-8

Target & IC50

Human NK1 receptor: ic50 10.6 (pki)
Rat NK1 receptor: ic50 9.5 (pki)
Ferret NK1 receptor: ic50 9.8 (pki)

In Vitro

The number of choices of the 25-s delayed reward in a T-maze increased by Vofopitant (30mg/kg, s.c.)[2]. Vofopitant (30mg/kg, i.p.) increases the extracellular 5-HT levels in the frontal cortex of paroxetine-treated wild-type mice, rather than in wild-type mice and paroxetine-treated NK1 receptor knockout mice[3].

Product Categories/Family for Vofopitant, inhibitor

Neuroscience; Neurokinin 1

Product References and Citations for Vofopitant, inhibitor

Gardner CJ, et al. GR205171: a novel antagonist with high affinity for the tachykinin NK1 receptor, and potent broad-spectrum anti-emetic activity. Regul Pept. 1996 Aug 27;65(1):45-53.
Gardner CJ, et al. GR205171: a novel antagonist with high affinity for the tachykinin NK1 receptor, and potent broad-spectrum anti-emetic activity. Regul Pept. 1996 Aug 27;65(1):45-53.
Loiseau F, et al. Antidepressant-like effects of agomelatine, melatonin and the NK1 receptor antagonist GR205171 in impulsive-related behaviour in rats. Psychopharmacology (Berl). 2005 Oct;182(1):24-3Epub 2005 Sep 29.
Loiseau F, et al. Antidepressant-like effects of agomelatine, melatonin and the NK1 receptor antagonist GR205171 in impulsive-related behaviour in rats. Psychopharmacology (Berl). 2005 Oct;182(1):24-32. Epub 2005 Sep 29.
Guiard BP, et al. Blockade of substance P (neurokinin 1) receptors enhances extracellular serotonin when combined with a selective serotonin reuptake inhibitor: an in vivo microdialysis study in mice. J Neurochem. 2004 Apr;89(1):54-63.
Guiard BP, et al. Blockade of substance P (neurokinin 1) receptors enhances extracellular serotonin when combined with a selective serotonin reuptake inhibitor: an in vivo microdialysis study in mice. J Neurochem. 2004 Apr;89(1):54-63.

Other Notes

Small volumes of Vofopitant, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Vofopitant purchase

MBS5754125 is an inhibitor targeting Vofopitant.