XY101 Inhibitor

Name: XY101 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754136
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754136

XY101 is a selective, metabolically stable and orally available agonist of RORgamma inverse(IC50 of 30nM and a Kd of 380nM). More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

XY101, Inhibitor

Full Product Name

XY101

Product Gene Name

XY101, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

563.48

Solubility

DMSO: 250mg/mL (443.67mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C25H20F7NO4S

SMILES

O=S(C1=CC=C(CC(NC2=CC=C(C3=C(F)C=C(C(O)(C(F)(F)F)C(F)(F)F)C=C3)C=C2)=O)C=C1)(CC)=O

CAS Number

2349368-16-5

Target & IC50

RORgamma: ic50 380nM (kd)

In Vitro

XY101 effectively inhibits cell growth, colony formation and expression of androgen receptor (AR), AR-V7 and prostate specific antigen (PSA).

Product Categories/Family for XY101, inhibitor

Metabolism

Product References and Citations for XY101, inhibitor

Zhang Y, et al. Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable RORgamma Inverse Agonist for treatment,of Castration-Resistant Prostate Cancer. J Med Chem. 2019 May 9;62(9):4716-4730.

Other Notes

Small volumes of XY101, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for XY101 purchase

MBS5754136 is an inhibitor targeting XY101.