Y06137 Inhibitor

Name: Y06137 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754137
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754137

Y06137 is a potent and selective inhibitor of BET, and used for treatment,of castration-resistant prostate cancer (CRPC). Y06137 binds to the BRD4(1) bromodomain with a Kd of 81nM. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Y06137, Inhibitor

Full Product Name

Y06137

Product Gene Name

Y06137, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

444.57

Solubility

DMSO: 62.5mg/mL (140.59mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C27H32N4O2

SMILES

CC1=NOC(C1=C2)=CC=C2C3=NC(C=C4)=C(N3CC5CCCCC5)C=C4N6CCOC[C@@H]6C

CAS Number

2226534-49-0

Target & IC50

BRD41: ic50 81nM (kd)

In Vitro

In a C4-2B CRPC xenograft tumor model in mice, Y06137 (50mg/kg, i.p. injection, 5 times per week, 25 days) demonstrates therapeutic effects.

Product Categories/Family for Y06137, inhibitor

Cytoskeletal Signaling; PKC; Chromatin/Epigenetic

Product References and Citations for Y06137, inhibitor

Zhang M, et al. Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential treatment,of Castration-Resistant Prostate Cancer (CRPC). J Med Chem. 2018 Apr 12;61(7):3037-3058.

Other Notes

Small volumes of Y06137, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Y06137 purchase

MBS5754137 is an inhibitor targeting Y06137.