Zamifenacin fumarate Inhibitor

Name: Zamifenacin fumarate Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754153
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754153

Zamifenacin fumarate is a potent antagonist of gut-selective muscarinic M3 receptor. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Zamifenacin fumarate, Inhibitor

Full Product Name

Zamifenacin fumarate

Product Synonym Names

UK-76654 fumarate

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

531.6

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C31H33NO7

SMILES

OC(/C=C/C(O)=O)=O.N1(C[C@@H](CCC1)OC(C2=CC=CC=C2)C3=CC=CC=C3)CCC4=CC5=C(C=C4)OCO5

CAS Number

127308-98-9

Target & IC50

Muscarinic M3 receptor

In Vitro

Zamifenacin exhibits terminal elimination half-lives (mouse 2.1, rat 6.0 and, dog 1.1 h) due to high plasma clearance (68, 35, and 39mL/min/kg respectively combined with large volumes of distribution (12.5, 19.0, and 3.5L/kg respectively) following intravenous administration (mouse 5.3, rat 5.0 and, dog 1.0mg/kg)[2].

Product References and Citations for Zamifenacin fumarate, inhibitor

Houghton LA, et al. Zamifenacin (UK-76, 654) a potent gut M3 selective muscarinic antagonist, reduces colonic motor activity in patients with irritable bowel syndrome. Aliment Pharmacol Ther. 1997 Jun;11(3):561-8.
Houghton LA, et al. Zamifenacin (UK-76, 654) a potent gut M3 selective muscarinic antagonist, reduces colonic motor activity in patients with irritable bowel syndrome. Aliment Pharmacol Ther. 1997 Jun;11(3):561-8.
Beaumont KC, et al. Pharmacokinetics and metabolism of Zamifenacin in mouse, rat, dog and man. Xenobiotica. 1996 Apr;26(4):459-71.
Beaumont KC, et al. Pharmacokinetics and metabolism of Zamifenacin in mouse, rat, dog and man. Xenobiotica. 1996 Apr;26(4):459-71.

Other Notes

Small volumes of Zamifenacin fumarate, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

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MBS5754153 is an inhibitor targeting Zamifenacin fumarate.

Zamifenacin fumarate Inhibitor

Product Overview

Structure of Zamifenacin fumarate, inhibitor

Related Product Information for Zamifenacin fumarate, inhibitor

Product References and Citations for Zamifenacin fumarate, inhibitor

Other Notes

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