(+)-DHMEQ Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

261.23

DMSO: 100mg/mL (382.80mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

C13H11NO5

O=C(NC([C@@H](O)[C@@]1([H])O[C@@]21[H])=CC2=O)C3=CC=CC=C3O

287194-41-6

Nrf2

(+)-DHMEQ activates Nrf2, a transcription factor that can induce the expression of various antioxidant enzymes. (+)-DHMEQ activates Nrf2 in promoter reporter gene analysis. (+)-DHMEQ also increases the expression of target antioxidant proteins in nerve cell lines and eliminates reactive oxygen species (ROS)-induced cell deathours. ROS generating 6-hydroxydopamine hydrochloride (6-OHDA) induces the death of SK-N-SH cells, and (+)-DHMEQ decreases the cytotoxic effect of 6-OHDA, whereas its effect is weaker in Nrf2-knockdown cells prepared with siRNA. Thus, enhancement of the neural cell viability by (+)-DHMEQ is due to the activation of Nrf2.