5alpha-Pregnane-3beta,6alpha-diol-20-one Inhibitor

5alpha-Pregnane-3beta,6alpha-diol-20-one is a mitogenic metabolite of progesterone. It can be produced in starved androgen-responsive prostate cancer cells.

Zhang J, et al. Progesterone metabolism in human fibroblasts is independent of P-glycoprotein levels and Niemann-Pick type C disease. J Steroid Biochem Mol Biol. 1999 Sep-Oct;70(4-6):123-31.
Zhang J, et al. Progesterone metabolism in human fibroblasts is independent of P-glycoprotein levels and Niemann-Pick type C disease. J Steroid Biochem Mol Biol. 1999 Sep-Oct;70(4-6):123-31.
de Mello Martins AGG, et al. CYP17A1-independent production of the neurosteroid-derived 5alpha-pregnan-3beta,6alpha-diol-20-one in androgen-responsive prostate cancer cell lines under serum starvation and inhibition by Abiraterone. J Steroid Biochem Mol Biol. 2017 Nov;174:183-191.
de Mello Martins AGG, et al. CYP17A1-independent production of the neurosteroid-derived 5alpha-pregnan-3beta,6alpha-diol-20-one in androgen-responsive prostate cancer cell lines under serum starvation and inhibition by Abiraterone. J Steroid Biochem Mol Biol. 2017 Nov;174:183-191.

Small volumes of 5alpha-Pregnane-3beta,6alpha-diol-20-one, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5754234 is an inhibitor targeting 5alpha-Pregnane-3beta,6alpha-diol-20-one.