Arimoclomol maleate Inhibitor

Name: Arimoclomol maleate Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754244
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754244

MBS5754244 is an inhibitor targeting Arimoclomol maleate. Arimoclomol maleate (BRX-220) is a heat shock protein (HSP) co-inducer. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Arimoclomol maleate, Inhibitor

Full Product Name

Arimoclomol maleate

Product Synonym Names

BRX-220

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

429.85

Solubility

DMSO: 250mg/mL (581.60mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C18H24ClN3O7

SMILES

Cl/C(C(C=CC=1)=CN1=O)=N\OC[C@H](O)CN2CCCCC2.OC(/C=C\C(O)=O)=O

CAS Number

289893-26-1

Target & IC50

HSP

In Vitro

Arimoclomol, administered for 5 d, has a protective effect against CCK-induced acute pancreatitis. Repeated CCK treatment,results in the typical laboratory and morphological changes of experimentally induced pancreatitis. The pancreatic levels of HSP60 and HSP72 are significantly increased in the animals treated with Arimoclomol [1]. Arimoclomol is a co-inducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis (ALS), the most common form of motor neuron disease [2].

Product References and Citations for Arimoclomol maleate, inhibitor

Rakonczay Z Jr, et al. Nontoxic heat shock protein coinducer BRX-220 protects against acute pancreatitis in rats. Free Radic Biol Med. 2002 Jun 15;32(12):1283-92.
Rakonczay Z Jr, et al. Nontoxic heat shock protein coinducer BRX-220 protects against acute pancreatitis in rats. Free Radic Biol Med. 2002 Jun 15;32(12):1283-92.
Phukan J. Arimoclomol, a coinducer of heat shock proteins for the potential treatment,of amyotrophic lateral sclerosis. IDrugs. 2010 Jul;13(7):482-96.
Phukan J. Arimoclomol, a coinducer of heat shock proteins for the potential treatment,of amyotrophic lateral sclerosis. IDrugs. 2010 Jul;13(7):482-96.

Other Notes

Small volumes of Arimoclomol maleate, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Arimoclomol maleate Inhibitor

Product Overview

Structure of Arimoclomol maleate, inhibitor

Related Product Information for Arimoclomol maleate, inhibitor

Product References and Citations for Arimoclomol maleate, inhibitor

Other Notes