• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Cloperastine fendizoate Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754271

Cloperastine fendizoate inhibits the hERG K+ currents in a concentration-dependent manner (IC50: 27nM). More details

Please Inquire
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Cloperastine fendizoate, Inhibitor
Full Product Name
Cloperastine fendizoate
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
648.19
Solubility
DMSO: 10mg/mL (15.43mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C40H38ClNO5
SMILES
O=C(O)C1=CC=CC=C1C(C2=CC(C3=CC=CC=C3)=C(O)C=C2)=O.ClC4=CC=C(C(C5=CC=CC=C5)OCCN6CCCCC6)C=C4
CAS Number
85187-37-7
Target & IC50
K+ currents: ic50 27nM
In Vitro
In the anesthetized guinea pigs, Cloperastine at a therapeutic dose of 1mg/kg prolonged the QT interval and monophasic action potential duration without affecting PR interval or QRS width [1]. Cloperastine hydrochloride shows relatively low acute toxicity when administered by the intraperitoneal route in rats and mice, and shows minor toxicity by the oral route when administered as Cloperastine fendizoate, the LD50 in rats and mice for the two administration routes exceeds 1000 and 2000mg/kg, respectively [2].

Structure of Cloperastine fendizoate, inhibitor

Cloperastine fendizoate Inhibitor – Cat# MBS5754271

Product References and Citations for Cloperastine fendizoate, inhibitor

Takahara A, et al. Effects of the antitussive drug cloperastine on ventricular repolarization in halothane-anesthetized guinea pigs. J Pharmacol Sci. 2012;120(3):165-75.
Takahara A, et al. Effects of the antitussive drug cloperastine on ventricular repolarization in halothane-anesthetized guinea pigs. J Pharmacol Sci. 2012;120(3):165-75.
Catania MA, et al. Pharmacological and clinical overview of cloperastine in treatment,of cough. Ther Clin Risk Manag. 2011;7:83-92.
Catania MA, et al. Pharmacological and clinical overview of cloperastine in treatment,of cough. Ther Clin Risk Manag. 2011;7:83-92.

Other Notes

Small volumes of Cloperastine fendizoate, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Cloperastine fendizoate purchase

MBS5754271 is an inhibitor targeting Cloperastine fendizoate.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000