GLPG2451 Inhibitor

Name: GLPG2451 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754311
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754311

GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. It effectively potentiates low temperature rescued F508del CFTR (EC50: 11.1nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GLPG2451, Inhibitor

Full Product Name

GLPG2451

Product Gene Name

GLPG2451, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

419.38

Solubility

DMSO: 270mg/mL (643.81mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C16H16F3N3O5S

SMILES

O=S(C1=CC=C(OC(F)(F)F)C=C1)(C2=CN=C(C(NC[C@@H](O)C)=O)C(N)=C2)=O

CAS Number

2055015-61-5

Target & IC50

Cystic fibrosis transmembrane conductance regulator

Product Categories/Family for GLPG2451, inhibitor

Proteases/Proteasome; Cysteine Protease

Product References and Citations for GLPG2451, inhibitor

Gees M, et al. Identification and Characterization of Novel CFTR Potentiators. Front Pharmacol. 2018 Oct 26;9:1221.
Gees M, et al. Identification and Characterization of Novel CFTR Potentiators. Front Pharmacol. 2018 Oct 26;9:1221.

Other Notes

Small volumes of GLPG2451, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GLPG2451 purchase

MBS5754311 is an inhibitor targeting GLPG2451.