GSK9311 Inhibitor

Name: GSK9311 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754316
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754316

GSK9311 inhibits BRPF bromodomain (pIC50: 6.0 and 4.3 for BRPF1 and BRPF2, respectively). GSK9311 is a less active analog of GSK6853. It can be used as a negative control. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GSK9311, Inhibitor

Full Product Name

GSK9311

Product Gene Name

GSK9311, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

437.53

Solubility

DMSO: 30mg/mL (68.57mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C24H31N5O3

SMILES

C[C@@H]1CNCCN1C2=C(N(CC)C(C3=CC=CC=C3OC)=O)C=C(C(N4C)=C2)N(C)C4=O

CAS Number

1923851-49-3

Target & IC50

BRPF1: ic50 6.0 (pic50)
BRPF2: ic50 4.3 (pic50)

In Vitro

GSK6853 is a less active analogue of GSK6853 in which the 5-amide is alkylated. GSK6853 is a potent (300 pM), soluble, cell active (20nM), and highly selective inhibitor of the BRPF1 bromodomain. GSK6853 shows properties suitable for cellular and in vivo studies[1].

Product Categories/Family for GSK9311, inhibitor

Chromatin/Epigenetic; Epigenetic Reader Domain; Epigenetics

Product References and Citations for GSK9311, inhibitor

Bamborough P, et al. GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain. ACS Med Chem Lett. 2016 May 9;7(6):552-7.
Bamborough P, et al. GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain. ACS Med Chem Lett. 2016 May 9;7(6):552-7.

Other Notes

Small volumes of GSK9311, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GSK9311 purchase

MBS5754316 is an inhibitor targeting GSK9311.