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Homo-pVHL30 degrader 1 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754321

MBS5754321 is an inhibitor targeting Homo-pVHL30 degrader 1. Also known as Homo-PROTAC pVHL30 degrader 1. Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Homo-pVHL30 degrader 1, Inhibitor
Full Product Name
Homo-PROTAC pVHL30 degrader 1
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
1179.45
Solubility
DMSO: 150mg/mL (127.18mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C58H82N8O14S2
SMILES
CC1=C(C2=CC=C(CNC([C@@H]3C[C@@]([H])(O)CN3C([C@H](C(C)(C)C)NC(COCCOCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@]([H])(O)C4)=O)=O)=O)=O)=O)C=C2)SC=N1
CAS Number
2244684-49-7
Target & IC50
VHL
In Vitro
Homo-PROTAC pVHL30 degrader 1 dimerizes von Hippel-Lindau (VHL) with high avidity in vitro and induces rapid, potent and proteasome-dependent self-degradation of VHL in different cell lines, in a highly isoform-selective fashion and without triggering a hypoxic response.

Product Categories/Family for Homo-pVHL30 degrader 1, inhibitor

PROTAC

Product References and Citations for Homo-pVHL30 degrader 1, inhibitor

Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017 Oct 10;8(1):830.
Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017 Oct 10;8(1):830.

Other Notes

Small volumes of Homo-pVHL30 degrader 1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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