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KRN5 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754333

KRN5 has potential to treat NFAT5-mediated Chronic Arthritis. KRN5, a derivative of KRN2, is an oral active Nuclear factor of activated T cells 5 (NFAT5) suppressor, with an IC50 of 750nM. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
KRN5, Inhibitor
Full Product Name
KRN5
Product Gene Name
KRN5, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
459.47
Solubility
DMSO: 6mg/mL (13.06mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C27H22FNO5
SMILES
COC1=C(OC)C2=C(C=C1)C(CC3=CC=CC=C3F)=C4N(C2=O)CCC(C4=C5)=CC6=C5OCO6
CAS Number
1800465-47-7
Target & IC50
NFAT5: ic50

Structure of KRN5, inhibitor

KRN5 Inhibitor – Cat# MBS5754333

Product References and Citations for KRN5, inhibitor

Han EJ, et al. Suppression of NFAT5-mediated Inflammation and Chronic Arthritis by Novel kappaB-binding Inhibitors. EBioMedicine. 2017 Apr;18:261-273.
Han EJ, et al. Suppression of NFAT5-mediated Inflammation and Chronic Arthritis by Novel kappaB-binding Inhibitors. EBioMedicine. 2017 Apr;18:261-273.

Other Notes

Small volumes of KRN5, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KRN5 purchase

MBS5754333 is an inhibitor targeting KRN5.
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