2-(Methylamino)-1H-purin-6(7H)-one Inhibitor

Name: 2-(Methylamino)-1H-purin-6(7H)-one Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754349
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754349

2-(Methylamino)-1H-purin-6(7H)-one is an endogenous methylated nucleoside found in human fluids, is a modified nucleoside. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

2-(Methylamino)-1H-purin-6(7H)-one, Inhibitor

Full Product Name

2-(Methylamino)-1H-purin-6(7H)-one

Product Synonym Names

N2-methylguanine

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

165.15

Solubility

DMSO: <1mg/mL (insoluble or slightly soluble)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C6H7N5O

SMILES

O=C1N=C(NC)NC2=C1NC=N2

CAS Number

10030-78-1

Target & IC50

Human Endogenous Metabolite

In Vitro

2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine) is the principal kinetic barrier for reverse transcription in the 1340 bases proximal to the 5' end of E Coli 16S rRNA. Transcription intermediates correspond to attenuation at the positions of 2-(Methylamino)-1H-purin-6(7H)-one in the rRNA sequence. The relaxation time for elongation of the cDNA through m2G is approximately 3 min[2].

Product Categories/Family for 2-(Methylamino)-1H-purin-6(7H)-one, inhibitor

Metabolic Enzyme/Protease

Product References and Citations for 2-(Methylamino)-1H-purin-6(7H)-one, inhibitor

Rife JP, et al. N 2-methylguanosine is iso-energetic with guanosine in RNA duplexes and GNRA tetraloops. Nucleic Acids Res. 1998 Aug 15;26(16):3640-4.
Rife JP, et al. N 2-methylguanosine is iso-energetic with guanosine in RNA duplexes and GNRA tetraloops. Nucleic Acids Res. 1998 Aug 15;26(16):3640-4.
Youvan DC, et al. Reverse transcriptase pauses at N2-methylguanine during in vitro transcription of Escherichia coli 16S ribosomal RNA. Proc Natl Acad Sci U S A. 1979 Aug;76(8):3751-4.
Youvan DC, et al. Reverse transcriptase pauses at N2-methylguanine during in vitro transcription of Escherichia coli 16S ribosomal RNA. Proc Natl Acad Sci U S A. 1979 Aug;76(8):3751-4.

Other Notes

Small volumes of 2-(Methylamino)-1H-purin-6(7H)-one, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

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MBS5754349 is an inhibitor targeting 2-(Methylamino)-1H-purin-6(7H)-one.