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FAK Inhibitor – Degrader 1

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754371

PROTAC FAK degrader 1 is a selective and potent degrader of focal adhesion kinase (Fak) (IC50 of 6.5nM). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FAK degrader 1, Inhibitor
Full Product Name
PROTAC FAK degrader 1
Product Gene Name
FAK, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
996.13
Solubility
DMSO: 200mg/mL (200.78mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C47H56F3N9O8S2
SMILES
O=C(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)CCOCCOC4=CC=C(NC5=NC(NCC6=CC=CC(N(C)S(C)(=O)=O)=C6)=C(C(F)(F)F)C=N5)C=C4
CAS Number
2301916-69-6
Target & IC50
Focal adhesion kinase: ic50 3nM (DC50)

Structure of FAK, inhibitor

FAK Inhibitor – Cat# MBS5754371

Product References and Citations for FAK, inhibitor

Cromm PM, et al. Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation. J Am Chem Soc. 2018 Dec 12;140(49):17019-17026.
Cromm PM, et al. Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation. J Am Chem Soc. 2018 Dec 12;140(49):17019-17026.

Other Notes

Small volumes of FAK, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FAK purchase

MBS5754371 is an inhibitor targeting FAK. Also known as PROTAC FAK degrader 1.
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