RA190 Inhibitor

Name: RA190 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754379
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754379

RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RA190, Inhibitor

Full Product Name

RA190

Product Gene Name

RA190, inhibitor

Form/Format

Solid. Powder

Purity/Purification

97.69%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

596.76

Solubility

DMSO: 95mg/ml (159.19mM)
H2O: <0.1mg/mL (insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C28H23Cl5N2O2

SMILES

Cl.N[C@@H](CC1=CC=CC=C1)C(=O)N1C\\C(=C/C2=CC(Cl)=C(Cl)C=C2)C(=O)\\C(C1)=C\\C1=CC(Cl)=C(Cl)C=C1

CAS Number

1617495-03-0

Target & IC50

HeLa cell: ic50 0.15uM
Proteasome

In Vitro

RA190 administration profoundly reduces growth of multiple myeloma and ovarian cancer xenografts, and oral RA190 treatment,retards HPV16+ syngeneic mouse tumor growth, without impacting spontaneous HPV-specific CD8+ T cell responses.

Product Categories/Family for RA190, inhibitor

Proteases/Proteasome; Proteasome

Product References and Citations for RA190, inhibitor

Anchoori RK, et al. A bis-benzylidine piperidone targeting proteasome ubiquitin receptor RPN13/ADRM1 as a therapy for cancer. Cancer Cell. 2013 Dec 9;24(6):791-805.

Other Notes

Small volumes of RA190, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RA190 purchase

MBS5754379 is an inhibitor targeting RA190.