Resorcinolnaphthalein Inhibitor

Name: Resorcinolnaphthalein Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754385
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754385

Resorcinolnaphthalein is a specific enhancer of angiotensin-converting enzyme 2 (ACE2) (EC50 value of 19.5uM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Resorcinolnaphthalein, Inhibitor

Full Product Name

Resorcinolnaphthalein

Form/Format

Solid. Powder

Purity/Purification

99.25%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

382.36

Solubility

DMSO: 120mg/mL (313.84mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C24H14O5

SMILES

Oc1ccc2c(Oc3cc(O)ccc3C22OC(=O)c3cccc4cccc2c34)c1

CAS Number

41307-63-5

Target & IC50

ACE2: ic50 19.5uM (EC50)

In Vitro

resorcinolnaphthalein enhanced ACE2 activity in a dose-dependent manner. Acute in vivo administration of the xanthenone resulted in a dose-dependent transient and robust decrease in blood pressure (at 10mg/kg, spontaneously hypertensive rats decreased 71+/-9mM Hg and Wistar-Kyoto rats decreased 21+/-8mM Hg; P<0.05). Chronic infusion of the xanthenone (120microg/day) resulted in a modest decrease in the spontaneously hypertensive rat blood pressure (17mM Hg; 2-way ANOVA; P<0.05), whereas it had no effect in Wistar-Kyoto rats. Strikingly, the decrease in blood pressure was also associated with improvements in cardiac function and reversal of myocardial, perivascular, and renal fibrosis in the spontaneously hypertensive rats[1].

Product Categories/Family for Resorcinolnaphthalein, inhibitor

Endocrinology/Hormones

Product References and Citations for Resorcinolnaphthalein, inhibitor

Hernandez Prada JA, et al.Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents.Hypertension. 2008 May;51(5):1312-7.
Hernandez Prada JA, et al.Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents.Hypertension. 2008 May;51(5):1312-7.

Other Notes

Small volumes of Resorcinolnaphthalein, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Resorcinolnaphthalein purchase

MBS5754385 is an inhibitor targeting Resorcinolnaphthalein.