UC-514321 Inhibitor

Name: UC-514321 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754410
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754410

UC-514321 is a structural analog of NSC370284 and has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

UC-514321, Inhibitor

Full Product Name

UC-514321

Product Gene Name

UC-514321, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

441.56

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C26H35NO5

SMILES

OC1=C(C(C2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2)N3CCOCC3)C=C(OCO4)C4=C1

CAS Number

299420-83-0

Target & IC50

STAT3

In Vitro

In AML mice models,UC-514321 (2.5mg/kg, ip, once per day, for 10 days) exhibits more potant anti-tumor activity than NSC370284.

Product Categories/Family for UC-514321, inhibitor

JAK/STAT signaling; STAT; Stem Cells

Product References and Citations for UC-514321, inhibitor

Jiang X, et al. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nat Commun. 2017 Dec 13;8(1):2099.

Other Notes

Small volumes of UC-514321, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for UC-514321 purchase

MBS5754410 is an inhibitor targeting UC-514321.