1G244 Inhibitor

Name: 1G244 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754424
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754424

1G244 is a potent DPP8/9 inhibitor with IC50s of 12nM and 84nM, respectively. 1G244 does not inhibit DPPIV and DPPII. 1G244 induces apoptosis in multiple myeloma cells and has anti-myeloma effects[1][2]. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

1G244, Inhibitor

Full Product Name

1G244

Product Gene Name

1G244, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

504.57

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C29H30F2N4O2

SMILES

O=C(N1CC2=C(C=CC=C2)C1)[C@@H](N)CC(N3CCN(C(C4=CC=C(F)C=C4)C5=CC=C(F)C=C5)CC3)=O

CAS Number

847928-32-9

Target & IC50

DPP8: ic50 12nM
DPP9: ic50 84nM

Product References and Citations for 1G244, inhibitor

Sato T, et al. DPP8 is a novel therapeutic target for multiple myeloma. Sci Rep. 2019 Dec 2;9(1):18094.
Sato T, et al. DPP8 is a novel therapeutic target for multiple myeloma. Sci Rep. 2019 Dec 2;9(1):18094.
Leen Heirbaut, et al. Probing for improved selectivity with dipeptidederived inhibitors of dipeptidyl peptidases 8 and 9: the impact of P1-variation. MedChemComm. 2016, 7.
Leen Heirbaut, et al. Probing for improved selectivity with dipeptidederived inhibitors of dipeptidyl peptidases 8 and 9: the impact of P1-variation. MedChemComm. 2016, 7.

Other Notes

Small volumes of 1G244, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

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MBS5754424 is an inhibitor targeting 1G244.

1G244 Inhibitor

Product Overview

Structure of 1G244, inhibitor

Related Product Information for 1G244, inhibitor

Product References and Citations for 1G244, inhibitor

Other Notes

Searchable Terms for 1G244 purchase